BCL-2 Inhibitor Market: By Product, By Type, and Region Forecast 2019-2030

BCL-2 (B-cell lymphoma 2) Inhibitor Market Size, Share, Growth, Trends, and Global Industry Analysis: By Product (Combination Therapy and Monotherapy), By Type (Diffuse Large B-cell Lymphoma, Follicular Lymphoma, Chronic Lymphocytic leukemia, and Mantle Cell Lymphoma), and Region Forecast 2019-2030

BCL-2 (B-cell lymphoma 2) Inhibitor Market was valued at US$ 2,768.7 million in 2023 and is poised to grow at a 12.9% CAGR from 2024 to 2030. BCL-2 is a selective inhibitor of the anti-apoptotic protein B-cell lymphoma 2 (Bcl-2), with potential pro-apoptotic and antineoplastic activities. Upon administration, Bcl-2 inhibitor BCL201 binds to and inhibits the activity of Bcl-2. This restores apoptotic processes in tumor cells. With the rising prevalence of haematological cancer worldwide the demand for B-cell lymphoma 2 (Bcl-2) increased.

According to the leukemic & Lymphoma Society, approximately every 3 minutes, one person in the US is diagnosed with leukemia, lymphoma, or myeloma, an estimated combined total of 186,400 people in the US are expected to be diagnosed with leukemia, lymphoma, or myeloma in 2021, new cases of leukemia, lymphoma and myeloma are expected to account for 9.8 percent of the estimated 1,898,160 new cancer cases that will be diagnosed in the US in 2021, the large number from the journal shows high extensive for B-cell lymphoma 2 (Bcl-2) inhibitors which drives the market. The increasing population of geriatric patients worldwide has escalated the BCL-2 market; drugs reached a large stage of development gradually impacting on growth of the market consequences resulting in lucrative opportunities in the market. Pharmaceutical companies and research organizations are continuously growing on novel drug development, but government regulations and clinical trials approval hinder the market growth which become major restraints in the B-cell lymphoma 2 (Bcl-2) inhibitor market. Geographically, North America held the major market share in 2022 and is expected to dominate the global BCL-2 market in the forecasted years due to global key players in this region.

Key Developments

  • In June 2022, Ascentage Pharma Releases Encouraging Results of Bcl-2 Inhibitor Lisaftoclax (APG-2575) in Chinese Patients with Relapsed/Refractory Non-Hodgkin Lymphoma.
  • In April 2021, the U.S. Food and Drug Administration (FDA) announced the approval of BCMA-targeted CAR T-Cell Therapy for the treatment of blood cancer. The current approval is based in part on the findings of small research that found that idecabtagene vicleucel (ide-cel) reduced tumor size in 72 percent of patients. These effects persisted on average for 11 months.

BCL-2 Inhibitor Market Summary

Study Period

2024-2030

Base Year

2023

CAGR

12.9%

Largest Market

North America

Fastest Growing Market

North America

BCL-2 Inhibitor Market Dynamics

The increasing prevalence of hematological diseases across the world is the major market driver in the BCL-2 Inhibitor Market during the forecast period. Blood cancer has become common among geriatric patients because it affects blood cells. Leukemia, lymphoma, and myeloma are some of the most common types of blood cancer. With the advanced development of novel drugs and continued approach towards health awareness in public about blood cancers, BCL-2 inhibitor drugs such as venetoclax and navitoclax selectively induce apoptosis in malignant cells reducing the risk factor, also increasing the demand for such drugs in the market which drives the market growth with significant growth.

BCL-2 Inhibitor Market Segmentation Analysis

Report Benchmarks

Details

Report Study Period

2024-2030

Market Size in 2023

US$ 2,768.7 million

Market CAGR

12.9%

By Product Type

  • Combination Therapy
  • Monotherapy

By Type

  • Diffuse Large B-cell Lymphoma
  • Follicular Lymphoma
  • Chronic Lymphocytic leukemia
  • Mantle Cell Lymphoma

By Region

  • North America
  • Europe
  • The Asia Pacific
  • Latin America
  • MEA

Key Features of the Report

  • The BCL-2 Inhibitor Market report provides granular level information about the market size, regional market share, historic market (2019-2023), and forecast (2024-2030)
  • The report covers in-detail insights about the competitor’s overview, company share analysis, key market developments, and key strategies.
  • The report outlines drivers, restraints, unmet needs, and trends that are currently affecting the market.
  • The report tracks recent innovations, key developments, and start-up details that are actively working in the market.
  • The report provides a plethora of information about market entry strategies, regulatory framework, and reimbursement scenarios.
  • The report analyses the impact of socio-political environment through PESTLE Analysis and competition through Porter's Five Force Analysis

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Frequently Asked Questions

Bcl-2 (b-cell lymphoma 2) inhibitor market size was valued at US$ 2,768.7 million in 2023 and is anticipated to garner at a CAGR of 12.9% from 2024-2030.

The BCL-2 Inhibitor Market is poised to grow at a significant CAGR of 12.9% from 2024 to 2030.

The leading players in the BCL-2 Inhibitor Market are Abcam plc, Amgen Inc., Novartis AG, Santa Cruz Biotechnology Inc., Seagen Inc., Servie, Biorbyt Ltd., Ascentage Pharma Group International, AstraZeneca Plc, BeiGene Ltd., Bio-Techne Corp., Biorbyt Ltd., Bristol Myers Squibb Co., F. Hoffmann La Roche Ltd., Ipsen Pharma, and Merck & Co. Inc.

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Author

Muni Kumar Meravath

Muni Kumar Meravath is a seasoned Healthcare Market Research Analyst with over 6 years of experience in the healthc.....

1.Executive Summary
2.Global BCL-2 Inhibitor Market Introduction 
2.1.Global BCL-2 Inhibitor Market  - Taxonomy
2.2.Global BCL-2 Inhibitor Market  - Definitions
2.2.1.Type 
2.2.2.Product Type
2.2.3.Geography
2.2.4.Region
3.Global BCL-2 Inhibitor Market Dynamics
3.1. Drivers
3.2. Restraints
3.3. Opportunities/Unmet Needs of the Market
3.4. Trends
3.5. Product Landscape
3.6. New Product Launches
3.7. Impact of COVID 19 on Market
4.Global BCL-2 Inhibitor Market Analysis, 2019 - 2023 and Forecast 2024 - 2030
4.1.  Market Analysis, 2019 - 2023 and Forecast, 2024 - 2030, (Sales Value USD Million)
4.2.  Year-Over-Year (Y-o-Y) Growth Analysis (%) 
4.3.  Market Opportunity Analysis 
5.Global BCL-2 Inhibitor Market  By Type , 2019 - 2023 and Forecast 2024 - 2030 (Sales Value USD Million)
5.1. Diffuse Large B-cell Lymphoma
5.1.1. Market Analysis, 2019 - 2023 and Forecast, 2024 - 2030, (Sales Value USD Million)
5.1.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) 
5.1.3. Market Opportunity Analysis 
5.2. Follicular Lymphoma
5.2.1. Market Analysis, 2019 - 2023 and Forecast, 2024 - 2030, (Sales Value USD Million)
5.2.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) 
5.2.3. Market Opportunity Analysis 
5.3. Chronic Lymphocytic leukemia
5.3.1. Market Analysis, 2019 - 2023 and Forecast, 2024 - 2030, (Sales Value USD Million)
5.3.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) 
5.3.3. Market Opportunity Analysis 
5.4. Mantle Cell Lymphoma
5.4.1. Market Analysis, 2019 - 2023 and Forecast, 2024 - 2030, (Sales Value USD Million)
5.4.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) 
5.4.3. Market Opportunity Analysis 
6.Global BCL-2 Inhibitor Market  By Product Type, 2019 - 2023 and Forecast 2024 - 2030 (Sales Value USD Million)
6.1. Combination Therapy
6.1.1. Market Analysis, 2019 - 2023 and Forecast, 2024 - 2030, (Sales Value USD Million)
6.1.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) 
6.1.3. Market Opportunity Analysis 
6.2. Monotherapy
6.2.1. Market Analysis, 2019 - 2023 and Forecast, 2024 - 2030, (Sales Value USD Million)
6.2.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) 
6.2.3. Market Opportunity Analysis 
7.Global BCL-2 Inhibitor Market  By Geography, 2019 - 2023 and Forecast 2024 - 2030 (Sales Value USD Million)
7.1. North America
7.1.1. Market Analysis, 2019 - 2023 and Forecast, 2024 - 2030, (Sales Value USD Million)
7.1.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) 
7.1.3. Market Opportunity Analysis 
7.2. Europe
7.2.1. Market Analysis, 2019 - 2023 and Forecast, 2024 - 2030, (Sales Value USD Million)
7.2.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) 
7.2.3. Market Opportunity Analysis 
7.3. The Asia Pacific
7.3.1. Market Analysis, 2019 - 2023 and Forecast, 2024 - 2030, (Sales Value USD Million)
7.3.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) 
7.3.3. Market Opportunity Analysis 
7.4. Latin America
7.4.1. Market Analysis, 2019 - 2023 and Forecast, 2024 - 2030, (Sales Value USD Million)
7.4.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) 
7.4.3. Market Opportunity Analysis 
7.5. MEA
7.5.1. Market Analysis, 2019 - 2023 and Forecast, 2024 - 2030, (Sales Value USD Million)
7.5.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) 
7.5.3. Market Opportunity Analysis 
8.Global BCL-2 Inhibitor Market  By Region, 2019 - 2023 and Forecast 2024 - 2030 (Sales Value USD Million)
8.1. North America
8.1.1. Market Analysis, 2019 - 2023 and Forecast, 2024 - 2030, (Sales Value USD Million)
8.1.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) 
8.1.3. Market Opportunity Analysis 
8.2. Europe
8.2.1. Market Analysis, 2019 - 2023 and Forecast, 2024 - 2030, (Sales Value USD Million)
8.2.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) 
8.2.3. Market Opportunity Analysis 
8.3. Asia Pacific (APAC)
8.3.1. Market Analysis, 2019 - 2023 and Forecast, 2024 - 2030, (Sales Value USD Million)
8.3.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) 
8.3.3. Market Opportunity Analysis 
8.4. Middle East and Africa (MEA)
8.4.1. Market Analysis, 2019 - 2023 and Forecast, 2024 - 2030, (Sales Value USD Million)
8.4.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) 
8.4.3. Market Opportunity Analysis 
8.5. Latin America
8.5.1. Market Analysis, 2019 - 2023 and Forecast, 2024 - 2030, (Sales Value USD Million)
8.5.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) 
8.5.3. Market Opportunity Analysis 
9.North America BCL-2 Inhibitor Market ,2019 - 2023 and Forecast 2024 - 2030 (Sales Value USD Million)
9.1. Type  Analysis 2019 - 2023 and Forecast 2024 - 2030 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) 
9.1.1.Diffuse Large B-cell Lymphoma
9.1.2.Follicular Lymphoma
9.1.3.Chronic Lymphocytic leukemia
9.1.4.Mantle Cell Lymphoma
9.2.  Product Type Analysis 2019 - 2023 and Forecast 2024 - 2030 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) 
9.2.1.Combination Therapy
9.2.2.Monotherapy
9.3.  Geography Analysis 2019 - 2023 and Forecast 2024 - 2030 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) 
9.3.1.North America
9.3.2.Europe
9.3.3.The Asia Pacific
9.3.4.Latin America
9.3.5.MEA
9.4.  Country Analysis 2019 - 2023 and Forecast 2024 - 2030 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) 
9.4.1.United States of America (USA)
9.4.2.Canada
10.Europe BCL-2 Inhibitor Market ,2019 - 2023 and Forecast 2024 - 2030 (Sales Value USD Million)
10.1. Type  Analysis  and Forecast  by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) 
10.1.1.Diffuse Large B-cell Lymphoma
10.1.2.Follicular Lymphoma
10.1.3.Chronic Lymphocytic leukemia
10.1.4.Mantle Cell Lymphoma
10.2.  Product Type Analysis 2019 - 2023 and Forecast 2024 - 2030 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) 
10.2.1.Combination Therapy
10.2.2.Monotherapy
10.3.  Geography Analysis 2019 - 2023 and Forecast 2024 - 2030 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) 
10.3.1.North America
10.3.2.Europe
10.3.3.The Asia Pacific
10.3.4.Latin America
10.3.5.MEA
10.4.  Country Analysis 2019 - 2023 and Forecast 2024 - 2030 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) 
10.4.1.Germany
10.4.2.France
10.4.3.Italy
10.4.4.United Kingdom (UK)
10.4.5.Spain
11.Asia Pacific (APAC) BCL-2 Inhibitor Market ,2019 - 2023 and Forecast 2024 - 2030 (Sales Value USD Million)
11.1. Type  Analysis  and Forecast  by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) 
11.1.1.Diffuse Large B-cell Lymphoma
11.1.2.Follicular Lymphoma
11.1.3.Chronic Lymphocytic leukemia
11.1.4.Mantle Cell Lymphoma
11.2.  Product Type Analysis 2019 - 2023 and Forecast 2024 - 2030 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) 
11.2.1.Combination Therapy
11.2.2.Monotherapy
11.3.  Geography Analysis 2019 - 2023 and Forecast 2024 - 2030 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) 
11.3.1.North America
11.3.2.Europe
11.3.3.The Asia Pacific
11.3.4.Latin America
11.3.5.MEA
11.4.  Country Analysis 2019 - 2023 and Forecast 2024 - 2030 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) 
11.4.1.China
11.4.2.India
11.4.3.Australia and New Zealand (ANZ)
11.4.4.Japan
11.4.5.Rest of APAC
12.Middle East and Africa (MEA) BCL-2 Inhibitor Market ,2019 - 2023 and Forecast 2024 - 2030 (Sales Value USD Million)
12.1. Type  Analysis  and Forecast  by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) 
12.1.1.Diffuse Large B-cell Lymphoma
12.1.2.Follicular Lymphoma
12.1.3.Chronic Lymphocytic leukemia
12.1.4.Mantle Cell Lymphoma
12.2.  Product Type Analysis 2019 - 2023 and Forecast 2024 - 2030 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) 
12.2.1.Combination Therapy
12.2.2.Monotherapy
12.3.  Geography Analysis 2019 - 2023 and Forecast 2024 - 2030 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) 
12.3.1.North America
12.3.2.Europe
12.3.3.The Asia Pacific
12.3.4.Latin America
12.3.5.MEA
12.4.  Country Analysis 2019 - 2023 and Forecast 2024 - 2030 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) 
12.4.1.GCC Countries
12.4.2.South Africa
12.4.3.Rest of MEA
13.Latin America BCL-2 Inhibitor Market ,2019 - 2023 and Forecast 2024 - 2030 (Sales Value USD Million)
13.1. Type  Analysis  and Forecast  by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) 
13.1.1.Diffuse Large B-cell Lymphoma
13.1.2.Follicular Lymphoma
13.1.3.Chronic Lymphocytic leukemia
13.1.4.Mantle Cell Lymphoma
13.2.  Product Type Analysis 2019 - 2023 and Forecast 2024 - 2030 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) 
13.2.1.Combination Therapy
13.2.2.Monotherapy
13.3.  Geography Analysis 2019 - 2023 and Forecast 2024 - 2030 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) 
13.3.1.North America
13.3.2.Europe
13.3.3.The Asia Pacific
13.3.4.Latin America
13.3.5.MEA
13.4.  Country Analysis 2019 - 2023 and Forecast 2024 - 2030 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) 
13.4.1.Brazil
13.4.2.Mexico
13.4.3.Rest of LA
14. Competition Landscape
14.1.  Market Player Profiles (Introduction, Brand/Product Sales, Financial Analysis, Product Offerings, Key Developments, Collaborations, M & A, Strategies, and SWOT Analysis) 
14.2.1.Abcam plc
14.2.2.Amgen Inc.
14.2.3.Novartis AG
14.2.4.Santa Cruz Biotechnology Inc.
14.2.5.Seagen Inc.
14.2.6.Servie
14.2.7.Biorbyt Ltd.
14.2.8.Ascentage Pharma Group International
14.2.9.AstraZeneca Plc
14.2.10.BeiGene Ltd.
14.2.11.Bio Techne Corp.
14.2.12.Biorbyt Ltd.
14.2.13.Bristol Myers Squibb Co.
14.2.14.Hoffmann La Roche Ltd.
14.2.15.Ipsen Pharma
14.2.16.Merck and Co. Inc.
15. Research Methodology 
16. Appendix and Abbreviations 

Key Market Players

  • Abcam plc
  • Amgen Inc.
  • Novartis AG
  • Santa Cruz Biotechnology Inc.
  • Seagen Inc.
  • Servie
  • Biorbyt Ltd.
  • Ascentage Pharma Group International
  • AstraZeneca Plc
  • BeiGene Ltd.
  • Bio Techne Corp.
  • Biorbyt Ltd.
  • Bristol Myers Squibb Co.
  • Hoffmann La Roche Ltd.
  • Ipsen Pharma
  • Merck and Co. Inc.

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