Downstream Processing Market: By Product, By Technique, Purification Techniques, Solid-Liquid Separation, By Application, By End User and Region Forecast 2020-2031
Downstream Processing Market size was valued at US$ 34.56 billion in 2024 and is expected to reach US$ 95.35 billion by 2031, growing at a significant CAGR of 15.6% from 2025-2031. Downstream processing is the process of recovery and purification of the biosynthetic products. Biosynthetic products particularly pharmaceuticals, from natural sources such as plant or animal tissue or fermentation broth. The market may also include recycling of salvageable components and proper treatment of waste.
Furthermore, downstream processing is important step in manufacturing of hormones, antibiotics, antibodies, and vaccines. Stages include removal of insoluble, product isolation, product purification, product polishing and few recovery methods may be considered. The market is expected to grow at significant rates owing to the rise in demand for biopharmaceutical products. The market is consolidated due to presence of the many companies competing with product innovations and advancements. Companies are focusing on the R&D and new product launches to increase their product portfolio.
Study Period
2025-2031Base Year
2024CAGR
15.6%Largest Market
North-AmericaFastest Growing Market
Asia-Pacific
The market is mainly driven by the rise in R&D investment by the companies and government in the biopharmaceutical industry to produce more effective biopharmaceuticals. In addition, propelling demand for biopharmaceuticals due to the rising prevalence of communicable diseases and chronic diseases such as cancer boosting the market growth over the forecast period. Furthermore, technological developments in purification technology and need for highly pure biopharmaceuticals such as vaccines bolstering the global downstream processing market. However, lack of skilled professionals, high cost of devices and regulatory procedures are expected to hamper the market during the forecast period.
North America downstream processing market is expected to have major share in market owing to factors such as rise in R&D investment by the companies and government to develop new biopharmaceuticals for communicable diseases and cancer.
Europe is expected to expand at unprecedented growth rate owing to presence of key biopharmaceutical companies and significant growth in a number of market players.
Asia Pacific is projected to be fastest growing market in global market. The growth is attributed to surge in contract manufacturing organizations, increase in company and governments in product developments.
Latin America
Europe
Asia Pacific
Middle East
North America
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Report Benchmarks |
Details |
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Report Study Period |
2025-2031 |
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Market Size in 2024 |
US$ 34.56 billion |
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Market Size in 2031 |
US$ 95.35 billion |
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Market CAGR |
15.6% |
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By Product Type |
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By Technique |
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By Application |
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By End User |
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By Region |
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The global downstream processing market size was valued at US$ 34.56 billion in 2024 and is projected to grow at a CAGR of 15.6% from 2025 to 2031.
Asia-pacific is the fastest-growing region in the market.
In our report, we provide 12-15 market players’ information into the report. However, based on the client’s request we will provide additional country and regional market players information as well.
The key trend in the market is the growing adoption of single-use technologies to improve flexibility and reduce operational costs in biopharmaceutical manufacturing processes.
| 1.Executive Summary |
| 2.Global Downstream Processing Market Introduction |
| 2.1.Global Downstream Processing Market - Taxonomy |
| 2.2.Global Downstream Processing Market - Definitions |
| 2.2.1.Product Type |
| 2.2.2.Technique |
| 2.2.3.Application |
| 2.2.4.End User |
| 2.2.5.Region |
| 3.Global Downstream Processing Market Dynamics |
| 3.1. Drivers |
| 3.2. Restraints |
| 3.3. Opportunities/Unmet Needs of the Market |
| 3.4. Trends |
| 3.5. Product Landscape |
| 3.6. New Product Launches |
| 3.7. Impact of COVID 19 on Market |
| 4.Global Downstream Processing Market Analysis, 2020 - 2024 and Forecast 2025 - 2031 |
| 4.1. Market Analysis, 2020 - 2024 and Forecast, 2025 - 2031, (Sales Value USD Million) |
| 4.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) |
| 4.3. Market Opportunity Analysis |
| 5.Global Downstream Processing Market By Product Type, 2020 - 2024 and Forecast 2025 - 2031 (Sales Value USD Million) |
| 5.1. Membrane Adsorbents |
| 5.1.1. Market Analysis, 2020 - 2024 and Forecast, 2025 - 2031, (Sales Value USD Million) |
| 5.1.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) |
| 5.1.3. Market Opportunity Analysis |
| 5.2. Chromatography Columns and Resins |
| 5.2.1. Market Analysis, 2020 - 2024 and Forecast, 2025 - 2031, (Sales Value USD Million) |
| 5.2.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) |
| 5.2.3. Market Opportunity Analysis |
| 5.3. Filters |
| 5.3.1. Market Analysis, 2020 - 2024 and Forecast, 2025 - 2031, (Sales Value USD Million) |
| 5.3.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) |
| 5.3.3. Market Opportunity Analysis |
| 5.4. Others |
| 5.4.1. Market Analysis, 2020 - 2024 and Forecast, 2025 - 2031, (Sales Value USD Million) |
| 5.4.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) |
| 5.4.3. Market Opportunity Analysis |
| 6.Global Downstream Processing Market By Technique, 2020 - 2024 and Forecast 2025 - 2031 (Sales Value USD Million) |
| 6.1. Purification Techniques |
| 6.1.1. Market Analysis, 2020 - 2024 and Forecast, 2025 - 2031, (Sales Value USD Million) |
| 6.1.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) |
| 6.1.3. Market Opportunity Analysis |
| 6.2. Concentration/Clarification |
| 6.2.1. Market Analysis, 2020 - 2024 and Forecast, 2025 - 2031, (Sales Value USD Million) |
| 6.2.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) |
| 6.2.3. Market Opportunity Analysis |
| 7.Global Downstream Processing Market By Application, 2020 - 2024 and Forecast 2025 - 2031 (Sales Value USD Million) |
| 7.1. Vaccine Production |
| 7.1.1. Market Analysis, 2020 - 2024 and Forecast, 2025 - 2031, (Sales Value USD Million) |
| 7.1.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) |
| 7.1.3. Market Opportunity Analysis |
| 7.2. Monoclonal Antibodies Production |
| 7.2.1. Market Analysis, 2020 - 2024 and Forecast, 2025 - 2031, (Sales Value USD Million) |
| 7.2.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) |
| 7.2.3. Market Opportunity Analysis |
| 7.3. Insulin Production |
| 7.3.1. Market Analysis, 2020 - 2024 and Forecast, 2025 - 2031, (Sales Value USD Million) |
| 7.3.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) |
| 7.3.3. Market Opportunity Analysis |
| 7.4. Erythropoietin Production |
| 7.4.1. Market Analysis, 2020 - 2024 and Forecast, 2025 - 2031, (Sales Value USD Million) |
| 7.4.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) |
| 7.4.3. Market Opportunity Analysis |
| 7.5. Immunoglobulin Production |
| 7.5.1. Market Analysis, 2020 - 2024 and Forecast, 2025 - 2031, (Sales Value USD Million) |
| 7.5.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) |
| 7.5.3. Market Opportunity Analysis |
| 7.6. Others |
| 7.6.1. Market Analysis, 2020 - 2024 and Forecast, 2025 - 2031, (Sales Value USD Million) |
| 7.6.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) |
| 7.6.3. Market Opportunity Analysis |
| 8.Global Downstream Processing Market By End User, 2020 - 2024 and Forecast 2025 - 2031 (Sales Value USD Million) |
| 8.1. Biopharmaceutical Manufacturers |
| 8.1.1. Market Analysis, 2020 - 2024 and Forecast, 2025 - 2031, (Sales Value USD Million) |
| 8.1.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) |
| 8.1.3. Market Opportunity Analysis |
| 8.2. Contract Manufacturing Organizations |
| 8.2.1. Market Analysis, 2020 - 2024 and Forecast, 2025 - 2031, (Sales Value USD Million) |
| 8.2.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) |
| 8.2.3. Market Opportunity Analysis |
| 8.3. Others |
| 8.3.1. Market Analysis, 2020 - 2024 and Forecast, 2025 - 2031, (Sales Value USD Million) |
| 8.3.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) |
| 8.3.3. Market Opportunity Analysis |
| 9.Global Downstream Processing Market By Region, 2020 - 2024 and Forecast 2025 - 2031 (Sales Value USD Million) |
| 9.1. North America |
| 9.1.1. Market Analysis, 2020 - 2024 and Forecast, 2025 - 2031, (Sales Value USD Million) |
| 9.1.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) |
| 9.1.3. Market Opportunity Analysis |
| 9.2. Europe |
| 9.2.1. Market Analysis, 2020 - 2024 and Forecast, 2025 - 2031, (Sales Value USD Million) |
| 9.2.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) |
| 9.2.3. Market Opportunity Analysis |
| 9.3. Asia Pacific (APAC) |
| 9.3.1. Market Analysis, 2020 - 2024 and Forecast, 2025 - 2031, (Sales Value USD Million) |
| 9.3.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) |
| 9.3.3. Market Opportunity Analysis |
| 9.4. Middle East and Africa (MEA) |
| 9.4.1. Market Analysis, 2020 - 2024 and Forecast, 2025 - 2031, (Sales Value USD Million) |
| 9.4.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) |
| 9.4.3. Market Opportunity Analysis |
| 9.5. Latin America |
| 9.5.1. Market Analysis, 2020 - 2024 and Forecast, 2025 - 2031, (Sales Value USD Million) |
| 9.5.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) |
| 9.5.3. Market Opportunity Analysis |
| 10.North America Downstream Processing Market ,2020 - 2024 and Forecast 2025 - 2031 (Sales Value USD Million) |
| 10.1. Product Type Analysis 2020 - 2024 and Forecast 2025 - 2031 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) |
| 10.1.1.Membrane Adsorbents |
| 10.1.2.Chromatography Columns and Resins |
| 10.1.3.Filters |
| 10.1.4.Others |
| 10.2. Technique Analysis 2020 - 2024 and Forecast 2025 - 2031 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) |
| 10.2.1.Purification Techniques |
| 10.2.2.Concentration/Clarification |
| 10.3. Application Analysis 2020 - 2024 and Forecast 2025 - 2031 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) |
| 10.3.1.Vaccine Production |
| 10.3.2.Monoclonal Antibodies Production |
| 10.3.3.Insulin Production |
| 10.3.4.Erythropoietin Production |
| 10.3.5.Immunoglobulin Production |
| 10.3.6.Others |
| 10.4. End User Analysis 2020 - 2024 and Forecast 2025 - 2031 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) |
| 10.4.1.Biopharmaceutical Manufacturers |
| 10.4.2.Contract Manufacturing Organizations |
| 10.4.3.Others |
| 10.5. Country Analysis 2020 - 2024 and Forecast 2025 - 2031 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) |
| 10.5.1.United States of America (USA) |
| 10.5.2.Canada |
| 11.Europe Downstream Processing Market ,2020 - 2024 and Forecast 2025 - 2031 (Sales Value USD Million) |
| 11.1. Product Type Analysis and Forecast by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) |
| 11.1.1.Membrane Adsorbents |
| 11.1.2.Chromatography Columns and Resins |
| 11.1.3.Filters |
| 11.1.4.Others |
| 11.2. Technique Analysis 2020 - 2024 and Forecast 2025 - 2031 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) |
| 11.2.1.Purification Techniques |
| 11.2.2.Concentration/Clarification |
| 11.3. Application Analysis 2020 - 2024 and Forecast 2025 - 2031 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) |
| 11.3.1.Vaccine Production |
| 11.3.2.Monoclonal Antibodies Production |
| 11.3.3.Insulin Production |
| 11.3.4.Erythropoietin Production |
| 11.3.5.Immunoglobulin Production |
| 11.3.6.Others |
| 11.4. End User Analysis 2020 - 2024 and Forecast 2025 - 2031 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) |
| 11.4.1.Biopharmaceutical Manufacturers |
| 11.4.2.Contract Manufacturing Organizations |
| 11.4.3.Others |
| 11.5. Country Analysis 2020 - 2024 and Forecast 2025 - 2031 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) |
| 11.5.1.Germany |
| 11.5.2.France |
| 11.5.3.Italy |
| 11.5.4.United Kingdom (UK) |
| 11.5.5.Spain |
| 11.5.6.Rest of EU |
| 11.5.7. |
| 12.Asia Pacific (APAC) Downstream Processing Market ,2020 - 2024 and Forecast 2025 - 2031 (Sales Value USD Million) |
| 12.1. Product Type Analysis and Forecast by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) |
| 12.1.1.Membrane Adsorbents |
| 12.1.2.Chromatography Columns and Resins |
| 12.1.3.Filters |
| 12.1.4.Others |
| 12.2. Technique Analysis 2020 - 2024 and Forecast 2025 - 2031 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) |
| 12.2.1.Purification Techniques |
| 12.2.2.Concentration/Clarification |
| 12.3. Application Analysis 2020 - 2024 and Forecast 2025 - 2031 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) |
| 12.3.1.Vaccine Production |
| 12.3.2.Monoclonal Antibodies Production |
| 12.3.3.Insulin Production |
| 12.3.4.Erythropoietin Production |
| 12.3.5.Immunoglobulin Production |
| 12.3.6.Others |
| 12.4. End User Analysis 2020 - 2024 and Forecast 2025 - 2031 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) |
| 12.4.1.Biopharmaceutical Manufacturers |
| 12.4.2.Contract Manufacturing Organizations |
| 12.4.3.Others |
| 12.5. Country Analysis 2020 - 2024 and Forecast 2025 - 2031 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) |
| 12.5.1.China |
| 12.5.2.India |
| 12.5.3.Australia and New Zealand (ANZ) |
| 12.5.4.Japan |
| 12.5.5.Rest of APAC |
| 13.Middle East and Africa (MEA) Downstream Processing Market ,2020 - 2024 and Forecast 2025 - 2031 (Sales Value USD Million) |
| 13.1. Product Type Analysis and Forecast by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) |
| 13.1.1.Membrane Adsorbents |
| 13.1.2.Chromatography Columns and Resins |
| 13.1.3.Filters |
| 13.1.4.Others |
| 13.2. Technique Analysis 2020 - 2024 and Forecast 2025 - 2031 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) |
| 13.2.1.Purification Techniques |
| 13.2.2.Concentration/Clarification |
| 13.3. Application Analysis 2020 - 2024 and Forecast 2025 - 2031 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) |
| 13.3.1.Vaccine Production |
| 13.3.2.Monoclonal Antibodies Production |
| 13.3.3.Insulin Production |
| 13.3.4.Erythropoietin Production |
| 13.3.5.Immunoglobulin Production |
| 13.3.6.Others |
| 13.4. End User Analysis 2020 - 2024 and Forecast 2025 - 2031 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) |
| 13.4.1.Biopharmaceutical Manufacturers |
| 13.4.2.Contract Manufacturing Organizations |
| 13.4.3.Others |
| 13.5. Country Analysis 2020 - 2024 and Forecast 2025 - 2031 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) |
| 13.5.1.GCC Countries |
| 13.5.2.South Africa |
| 13.5.3.Rest of MEA |
| 14.Latin America Downstream Processing Market ,2020 - 2024 and Forecast 2025 - 2031 (Sales Value USD Million) |
| 14.1. Product Type Analysis and Forecast by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) |
| 14.1.1.Membrane Adsorbents |
| 14.1.2.Chromatography Columns and Resins |
| 14.1.3.Filters |
| 14.1.4.Others |
| 14.2. Technique Analysis 2020 - 2024 and Forecast 2025 - 2031 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) |
| 14.2.1.Purification Techniques |
| 14.2.2.Concentration/Clarification |
| 14.3. Application Analysis 2020 - 2024 and Forecast 2025 - 2031 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) |
| 14.3.1.Vaccine Production |
| 14.3.2.Monoclonal Antibodies Production |
| 14.3.3.Insulin Production |
| 14.3.4.Erythropoietin Production |
| 14.3.5.Immunoglobulin Production |
| 14.3.6.Others |
| 14.4. End User Analysis 2020 - 2024 and Forecast 2025 - 2031 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) |
| 14.4.1.Biopharmaceutical Manufacturers |
| 14.4.2.Contract Manufacturing Organizations |
| 14.4.3.Others |
| 14.5. Country Analysis 2020 - 2024 and Forecast 2025 - 2031 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) |
| 14.5.1.Brazil |
| 14.5.2.Mexico |
| 14.5.3.Rest of LA |
| 15. Competition Landscape |
| 15.1. Market Player Profiles (Introduction, Brand/Product Sales, Financial Analysis, Product Offerings, Key Developments, Collaborations, M & A, Strategies, and SWOT Analysis) |
| 15.2.1.Boehringer Ingelheim GmbH (Germany) |
| 15.2.2.3M Company (U.S.) |
| 15.2.3.Eppendorf AG (Germany) |
| 15.2.4.Danaher Corporation (U.S.) |
| 15.2.5.General Electric (U.S.) |
| 15.2.6.Finesse Solutions, Inc. (Thermo Fisher Scientific) (U.S.) |
| 15.2.7.Merck KGaA (Germany) |
| 15.2.8.Lonza Group AG (Switzerland) |
| 16. Research Methodology |
| 17. Appendix and Abbreviations |
Key Market Players
Author
Muni Kumar Meravath is a seasoned Healthcare Market Research Analyst with over 6 years of experience in the healthcare domain, encompassing pharmaceuticals, medical devices, and diagnostics. A graduate in Pharmacy, he possesses a strong foundation in the intricacies of the healthcare sector. He further enhanced his expertise by pursuing an MBA in Pharmaceuticals, equipping him with valuable business acumen. His analytical skills and market insights have contributed to strategic decision-making and enhanced market positioning for various healthcare organizations. Committed to driving innovation and excellence, Muni continues to seek opportunities to improve healthcare delivery through data-driven insights.
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