Global Dipeptidyl Peptidase IV Inhibitors Market
Dipeptidyl Peptidase IV (DPP-IV) inhibitors also known as gliptins are oral anti-diabetic drugs, commonly used in the treatment of Type-2 diabetes. Dipeptidyl Peptidase inhibitors act by inhibiting the degradation of incretins like GLP-1 by inhibition of the enzyme dipeptidyl peptidase IV. The effect of incretin is prolonged, improving the glycemic control by various mechanisms, initially by stimulating the insulin synthesis and secretion in a glucose-dependent manner and by reduction of glucagon secretion. Dipeptidyl Peptidase IV inhibitors are commonly prescribed for the patients with type 2 diabetes especially who are not responded well to sulfonyl ureas and metformin. Dipeptidyl Peptidase IV inhibitors decrease blood glucose levels and help in weight loss. The common adverse effects associated with DPP IV inhibitors is Pancreatitis.
The global dipeptidyl peptidase IV (DPP-IV) inhibitors market is expected to grow at a significant CAGR due to increase in the prevalence and incidence of diabetes. The excellent safety profile of dipeptidyl peptidase IV inhibitors, growing investments in the R&D activities, convenience benefit of being an oral medication, and acceptance of dipeptidyl peptidase IV inhibitors in oral antidiabetic drug class might fuel the dipeptidyl peptidase IV inhibitors market over the forecast period. Furthermore, favourable reimbursement policies for diabetes treatment, and low cost for dipeptidyl peptidase IV inhibitors expected to boost the dipeptidyl peptidase-IV inhibitors market over the forecast period. However, stringent regulatory policies, adverse effects associated with dipeptidyl peptidase IV inhibitors might hamper the dipeptidyl peptidase IV inhibitors market growth over the forecast period.
Dipeptidyl Peptidase IV (DPP-IV) Inhibitors market segmented on the basis of drug type, and distribution channel
Based on drug type, dipeptidyl peptidase IV Inhibitors market is segmented into the following:
Based on distribution channel, dipeptidyl peptidase IV Inhibitors market is segmented into the following:
- Hospital Pharmacies
- Retail Pharmacies
- Online Pharmacies
Geographically, dipeptidyl peptidase IV Inhibitors market is in booming stage in nature with several local and international players operating in the market. Increase in the prevalence and incidence of diabetic patients (According to the International Diabetes Federation, 7 million people are added every year to the pool of 246 million diabetics which increases to approximately 438 million by 2030. About 3.8 million People die each year from diabetes and even more, people die of other chronic diseases such as renal failure due to diabetes) expected to fuel the dipeptidyl peptidase IV inhibitors market. Launching of new products, approvals from various regulatory authorities such as U.S. Food and Drug Administration (U.S. FDA), acquisitions & mergers, and collaborations are some key strategies followed by various pharmaceutical companies for increasing their share in dipeptidyl peptidase IV inhibitors market. For instance, in March 2013, Otsuka obtains marketing approval in Japan for Onglyza tablets to treat Type 2 Diabetes. In April 2013, Takeda and Sanofi sign co-promotion agreement to expand the reach of diabetes treatment Alogliptin in China. Similarly, in February 2014, AstraZeneca completed the acquisition of Bristol-Myers Squibb share of the global diabetic alliance. Apart from this, in May 2011, Boehringer Ingelheim GMBH, and Eli Lilly and Co. announced that the U.S. Food and Drug Administration (FDA) has approved Tradjen (linagliptin) tablets, a prescription medication used along with diet and exercise to lower blood sugar in adults with type 2 diabetes. In June 2011, the Tradjen was approved by European Medicines Agency (EMEA) in the Europe.
Some of the players in dipeptidyl peptidase IV Inhibitors market are AstraZeneca Plc. (UK), Boehringer Ingelheim GmbH (Germany), Eli Lilly and Company (U.S.), Merck & Co, Inc. (U.S.), Mitsubishi Tanabe Pharma Corporation (Japan), Novartis AG (Switzerland), Takeda Pharmaceutical Company Limited (Japan), Sanofi (France), Bristol-Myers Squibb (U.S.), GlaxoSmithKline Plc. (U.K.), Pfizer, Inc. (U.S.), Otsuka Holdings Co. Ltd. (Japan), Ornamed Pharmaceutical, Inc. (Israel), Dr. Reddy’s Laboratories, Ltd. (India), and Novo Nordisk A/S (Denmark) to name a few.
- In July 2016, Sanofi-Synthelabo India Private Limited announced the launch of Zemiglo (gemigliptin) is a once daily, oral tablet
- In October 2015, Lupin and Boehringer Ingelheim announced that a joint strategic alliance for co-marketing Linagliptin, a novel dipeptidyl
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