In-Vitro Transcription Templates Market: By Product Type (DNA templates, RNA Templates, Templates and Transcription Kits, Other Product Types), By Disease Type (Cancer, Infectious Disease, Lifestyle Disease, Genetic Disease, Other Diseases), By Application (Research, Diagnostics, Therapeutics, Vaccines and Others), By Research stage (Explanatory, Clinical),By End User (Biotechnology & Pharmaceutical Companies, Academic & Research Institutes, Contract Research Organizations (CROs)) and Geography

In-Vitro Transcription Templates Market size was valued at USD 256.8 million in 2023 and is expected to grow at a 17.4% CAGR from 2024 to 2030. In-vitro transcription is a laboratory technique used to synthesize RNA molecules from a DNA template outside of living cells. In-vitro transcription templates are DNA sequences that contain all of the components required for transcription, such as a promoter recognized by RNA polymerase, the gene or sequence of interest, and a terminator. These templates can be obtained from plasmids, PCR products, or synthesized oligonucleotides and it provides a blueprint for RNA synthesis during in-vitro transcription. These templates find applications in molecular biology, including the study of gene function, production of RNA probes, etc.

The market for this is huge, as this is one of the centres of biotechnological research. Increase in the prevalence of chronic diseases and the need for new diagnostic and treatment strategies, increasing research activities, especially in molecular biology, genomics and transcriptomics, the growing biopharmaceutical sector, technological advancements and availability of research infrastructure and skilled labourers are the main factors driving the market. A noted point to mention, this technology was extensively used to find the mRNA-based vaccine for COVID-19, when most of the industries saw a downfall, this market was booming because of the ongoing research and its potential. Although all the driving factors are present, the high cost associated with high-purity enzymes, nucleotides, and specialized equipment and technological difficulties such as effective transcription templates and optimizing transcription reactions, faced while developing and using them are still major drawbacks for this market. However, investing heavily in biotechnology and life sciences research, taking this as an opportunity companies can enter into emerging markets. Also finding new applications are the templates can lead to future market growth, for example focusing on personalised medicine as patient-specific RNA sequence treatment.

In-Vitro Transcription Templates Market Key Developments:

• In September 2023, GenScript Biotech Corporation enhanced its IVT mRNA synthesis offerings by introducing personalized circular RNA (circRNA) and lipid nanoparticles (LNPs). GenScript has introduced new contract-manufactured reagent services as a demonstration of their state-of-the-art reagents that facilitate progress in areas such as vaccine development, protein replacement therapies, and gene and cell therapy.
• In September 2023, Merck became the first CT DMO to offer fully integrated services for mRNA development, manufacturing, commercialization, and product testing using Invitro Transcription template technology. This achievement was supported by the opening of two GMP- grade mRNA drug substance manufacturing sites in Darmstadt and Hamburg,
• In January 2023, NEB recently launched their HiScribe T7 High Yield RNA Synthesis Kit. This kit is designed for high-yield in-vitro transcription of RNA, offering improved efficiency and yield compared to previous versions. It includes optimized reagents and protocols for robust RNA synthesis applications.