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Muni Kumar Meravath is a seasoned Healthcare Market Research Analyst with over 6 years of experience in the healthc.....
Nucleoside Market: Competitive Landscape, Pipeline, and Market Analysis 2022
Nucleoside Market: Competitive Landscape, Pipeline, and Market Analysis 2022
A nucleoside is a molecule composed of a nucleobase (adenine, guanine, cytosine, thymine, or uracil) linked to a sugar (ribose or deoxyribose) via a glycosidic bond. It is a building block of nucleic acids like DNA and RNA. Nucleoside analogs are synthetic or modified nucleosides used as drugs that mimic natural nucleosides. They act by interfering with viral replication or DNA synthesis. Some nucleoside analogs, such as acyclovir, are used to treat viral infections like herpes, while others like azidothymidine (AZT) are used in the treatment of HIV/AIDS. According to the World Health Organization (WHO), an estimated 1.7 million people were living with HIV/AIDS in Europe, with approximately 141,000 new cases reported. In the United States, the Centers for Disease Control and Prevention (CDC) states that around 1.2 million people were living with HIV/AIDS, with about 37,968 new cases diagnosed. The prevalence of HIV/AIDS varies across countries in Europe, with Eastern Europe experiencing higher rates. In terms of herpes, the European Centre for Disease Prevention and Control (ECDC) reports that approximately 18 million people in the European Union are affected by genital herpes annually. In the United States, the CDC estimates that about one out of six people aged 14 to 49 years have genital herpes, with more women affected than men.
The growth drivers of the nucleoside stimulator market include the increasing prevalence of viral infections such as HIV and herpes, the growing demand for effective antiviral therapies, and the advancements in drug development technologies and research. Additionally, the rising awareness about the benefits of nucleoside analogs in treating viral diseases and the expanding healthcare infrastructure in developing regions contribute to the market's growth. Companies such as J&J, Merck (MSD), Fortress, SOM Biotech, PAION, Innoviva, and Viatris cater to this category. Moreover, many companies are coming up with new molecules in this space. For instance, MSD is conducting a clinical trial of the drug MK-8591 for the treatment of AIDS.
Nucleoside Market Key Developments:
In May 2022, Janssen Sciences completed the phase II PAINT trial of Rilpivirine in HIV-1 infections in USA, India, Kenya, Romania, South Africa, Thailand, Uganda and Ukraine
In March 2023, Merck Sharp & Dohme LLC preregistered Doravirine for HIV-1 infections (in children, in adults, in the elderly) in the USA
Approved Nucleoside molecules
Nucleoside Pipeline Molecules
Clinical Activity and Development of Nucleoside
In the Nucleoside space, more than 20 companies are conducting more than 150 clinical trials in this category of drugs. For instance,
|
Product Name |
Total Studies |
|
Islatravir (MK-8591) |
12 |
|
Doravirine, islatravir (MK-8591A) |
11 |
|
Sutezolid (PNU-100480) |
7 |
|
TP-271 |
4 |
|
Depulfavirine (VM-1500A-LAI) |
4 |
|
AZD5847 |
3 |
|
CMX157 |
3 |
|
PC-1005 gel |
2 |
|
Arbekacin (NPC-14) |
2 |
|
ADX-038 |
1 |
|
DuoGel (IQP-0528) |
1 |
Nucleoside drugs target various indications related to viral infections and DNA synthesis. One of the prominent indications is the treatment of human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS). Nucleoside analogs like zidovudine (AZT), which inhibits viral reverse transcriptase, are used as antiretroviral therapy for HIV/AIDS patients. Another indication is the management of herpes viral infections. Nucleoside analogs such as acyclovir and valacyclovir are commonly prescribed to reduce the severity and duration of outbreaks. Additionally, nucleoside drugs play a role in the treatment of certain cancers, where they inhibit DNA replication and disrupt tumor cell growth. These drugs have demonstrated efficacy in conditions such as leukemia and pancreatic cancer, among others.
The global Nucleoside market is segmented into the United States, United Kingdom, Germany, Spain, France, Italy, and Japan. The nucleoside market in the United States demonstrates a promising outlook. With a high prevalence of viral infections like HIV and herpes, the demand for nucleoside analogs as effective antiviral therapies remains substantial. The US market benefits from a well-established healthcare infrastructure, advanced research and development capabilities, and a stringent regulatory framework, which supports the development and commercialization of nucleoside drugs. Additionally, strategic collaborations between pharmaceutical companies, academic institutions, and research organizations contribute to innovation and market growth. The increasing geriatric population, rising healthcare expenditure, and growing awareness among healthcare professionals and patients about the benefits of nucleoside drugs further drive the market's expansion. Furthermore, advancements in drug development technologies and research facilitate the discovery of new and improved nucleoside-based treatments with enhanced efficacy and safety profiles. The nucleoside market in the US is poised for continuous growth as it addresses critical medical needs and fosters innovation in antiviral therapies Canada, on the other hand, is known for its well-established healthcare system and supportive regulatory framework, making it an attractive market for Nucleosides. These countries are increasingly adopting Nucleosides due to their efficacy and potential to improve patient outcomes. On the other hand, the Nucleoside market in Europe has witnessed significant growth in recent years. Major countries driving this market include Germany, France, Italy, and Spain. These countries have a robust pharmaceutical industry, which is a key driver for the Nucleoside market.
Latin America
Europe
Asia Pacific
Middle East
North America
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The major players in this space are J&J, Merck (MSD), Fortress, SOM Biotech, AstraZeneca, Viriom, Paradigm Biopharma, Nobelpharma, ADARx, Gilead, Kainos Medicine, ReCode Therap, Persica Pharma, Pfizer, Cipla, Bausth Health.
The nucleoside drug market faces certain restraints, including the potential for drug resistance development due to the prolonged use of nucleoside analogs, which can reduce their effectiveness over time. Additionally, the high cost of nucleoside drugs and the complex manufacturing processes associated with their production can pose financial challenges and limit access to these treatments, particularly in lower-income regions.
Key Market Players
Author
Muni Kumar Meravath is a seasoned Healthcare Market Research Analyst with over 6 years of experience in the healthcare domain, encompassing pharmaceuticals, medical devices, and diagnostics. A graduate in Pharmacy, he possesses a strong foundation in the intricacies of the healthcare sector. He further enhanced his expertise by pursuing an MBA in Pharmaceuticals, equipping him with valuable business acumen. His analytical skills and market insights have contributed to strategic decision-making and enhanced market positioning for various healthcare organizations. Committed to driving innovation and excellence, Muni continues to seek opportunities to improve healthcare delivery through data-driven insights.