Prosthetic Heart Valve Market size was valued at USD 6,815.2 million in 2021 and is poised to grow at a significant CAGR of 11.9% over 2022–2028. The four chambers of the human heart each have a valve to guarantee that blood only flows in one direction. The blood flows back into the atria or ventricles if any of the heart valves are leaking, constricted, swollen, or ruptured, placing extreme strain on the entire heart. The worst-case scenario here could result in arrhythmia or possibly heart failure. Prosthetic heart valves can be installed to fix the issue, depending on the defect’s severity. Due to the aging population, lack of physical activity, and bad diet, demand for this sort of surgery is predicted to increase dramatically over the next few decades in many regions worldwide. In 2050, around 850,000 people will need mechanical heart valves. Furthermore, according to the World Health Organization, about 2% of patients with cardiovascular diseases (CVDs) have rheumatic heart disorders. Therefore, the market is projected to benefit in the years to come from the rise of rheumatic heart disorders. Additionally, the hunt for an alternative to the replacement heart valves already in use began in 2019 by researchers at ETH Zurich and the South African business SAT. And with some success: they designed a silicone prosthetic heart valve that is produced using 3D printers in several processes.