RNA Synthesis Market: By Technology, By End-Use and Region Forecast 2019-2030

RNA Synthesis Market Size, Share, Growth, Trends, and Global Industry Analysis: By Technology (In-Vitro Transcription, In-Vivo Transcription, and Chemical Synthesis), By End-Use (Academic Research Institutes, Biopharmaceutical Companies, and Contract Research Organizations) and Region Forecast 2019-2030

RNA Synthesis Market size was valued at US$ 2,153.4 million in 2023 and is poised to grow at a CAGR of 19.9% from 2024 to 2030.  The Market is driven by the Growing prevalence of chronic and infectious diseases, the increasing adoption of RNA-based therapies & molecular diagnostics, and the increase in funding in life science, and technological advancements in RNA synthesis methods. However, technological complexity, side effects of mRNA vaccines affecting the market, and challenges for large-scale manufacturing of mRNA vaccines are the restraints of the market that can hinder market growth and need to be addressed.

Approximately one in three adults worldwide suffer from MCCs. However, there is no universally agreed-upon taxonomy for MCCs, leading to variations in prevalence rates. The global market presents several opportunities, including the development of new RNA-based therapies, increasing adoption of RNA interference (RNAi), and growing demand for personalized medicine. The global market is expected to continue to grow in the coming years, driven by the factors mentioned above. Some of the key trends in the market include strategic acquisitions and innovations in RNA synthesis technologies and increasing automation of RNA synthesis workflows, increasing use of RNA synthesis in synthetic biology.

The synergy between the rising demand for RNA-based diagnostics and increasing research funding is creating a fertile ground for the market. As RNA technologies continue to evolve, we can expect even more innovative diagnostic tools and personalized medicine approaches. This exciting future holds immense potential for improving healthcare outcomes and revolutionizing the way we diagnose and treat diseases.

Key Developments

  • In September 2022, Thermo Fisher Scientific’s scalable mRNA Production Solutions, utilizing customized Dynabeads. These solutions enable scalable, GMP-grade mRNA synthesis and purification for vaccine research and production
  • In Jan 2024, Merck, a leading science and technology company, announced a licensing agreement with Inspirna, Inc. for the first-in-class ompenaclid (rgx-202) currently in phase II development for RAS-mutated advanced or metastatic colorectal cancer, the collaboration includes exclusive license outside US with the option to co-develop and co-promote ompenaclid in US.

RNA Synthesis Market Summary

Study Period

2024 - 2030

Base Year

2023

CAGR

19.9%

Largest Market

North America

Fastest Growing Market

Asia Pacific

RNA Synthesis Market Dynamics

The world of molecular diagnostics is witnessing a significant shift towards RNA (ribonucleic acid). This surge in RNA adoption is driving a parallel growth in the RNA synthesis market, fuelled further by increasing research funding. Traditionally, DNA (deoxyribonucleic acid) has been the king of molecular diagnostics. However, RNA offers unique advantages. It plays a critical role in translating genetic information into proteins, the workhorses of cells. By analysing RNA, researchers can gain insights into cellular activity, disease progression, and even potential drug targets.

Techniques like RNA sequencing (RNA-Seq) allow scientists to map an entire cell's RNA profile, providing a deeper understanding of cellular processes. This newfound appreciation for RNA is transforming diagnostics. RT-PCR (reverse transcription polymerase chain reaction), a technique that utilizes RNA synthesis, has been instrumental in the fight against COVID-19.  Similarly, RNA-based tests are being developed for various diseases, including cancer and neurological disorders. These tests offer greater sensitivity and specificity compared to traditional methods, leading to earlier and more accurate diagnoses. The increasing adoption of RNA in diagnostics has attracted significant research funding from government agencies, private institutions, and pharmaceutical companies. This funding fuels advancements in RNA synthesis technologies. Companies are developing faster, more efficient, and cost-effective methods for synthesizing high-quality RNA. Additionally, research is ongoing to improve the stability and purity of synthetic RNA, making it even more versatile for diagnostic applications.

RNA Synthesis Market Segmentation Analysis

Report Benchmarks

Details

Report Study Period

2024 - 2030

Market Size in 2023

US$ 2,153.4 million

Market CAGR

19.9%

By Technology

  • In-Vitro Transcription
  • In-Vivo Transcription
  • Chemical Synthesis

By End User

  • Academic Research Institutes
  • Biopharmaceutical Companies
  • Contract Research Organization

By Region

  • North America (U.S., Canada)
  • Europe (Germany, U.K., France, Italy, Russia, Spain, Rest of Europe)
  • Asia-Pacific (China, India, Japan, Australia, Southeast Asia, Rest of Asia Pacific)
  • Latin America (Mexico, Brazil, Argentina, Columbia, Rest of Latin America)
  • Middle East & Africa (GCC, Egypt, Nigeria, South Africa, Rest of Middle East and Africa)

Key Features of the Report

  • The RNA synthesis market report provides granular level information about the market size, regional market share, historic market (2019-2023), and forecast (2024-2030)
  • The report covers in-detail insights about the competitor’s overview, company share analysis, key market developments, and key strategies.
  • The report outlines drivers, restraints, unmet needs, and trends that are currently affecting the market.
  • The report tracks recent innovations, key developments, and start-up details that are actively working in the market.
  • The report provides a plethora of information about market entry strategies, regulatory framework, and reimbursement scenarios.
  • The report analyses the impact of socio-political environment through PESTLE Analysis and competition through Porter's Five Force Analysis in addition to recent technology advancements and innovations in the market

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Frequently Asked Questions

The RNA synthesis market was valued at US$ 2,153.4 million in 2023 and is expected to reach US$ 6,403.0 million by 2029, growing at a CAGR of 19.9 %.

The RNA Synthesis Market is driven by the Growing prevalence of chronic and infectious diseases, the increasing adoption of RNA-based therapies & molecular diagnostics, and the increase in funding in life science, and technological advancements in RNA synthesis methods.

Technological complexity, side effects of mRNA vaccines affecting the RNA synthesis market, and challenges for large-scale manufacturing of mRNA vaccines are the restraints of the market.

Market research is segmented based on technology, end-use, and region.

Asai-Pacific is the fastest-growing region in the RNA Synthesis Market.

Author image

Author

Muni Kumar Meravath

Muni Kumar Meravath is a seasoned Healthcare Market Research Analyst with over 6 years of experience in the healthc.....

1.Executive Summary
2.Global RNA Synthesis Market Introduction 
2.1.Global RNA Synthesis Market  - Taxonomy
2.2.Global RNA Synthesis Market  - Definitions
2.2.1. Technology
2.2.2.End User
2.2.3.Geography
2.2.4.Region
3.Global RNA Synthesis Market Dynamics
3.1. Drivers
3.2. Restraints
3.3. Opportunities/Unmet Needs of the Market
3.4. Trends
3.5. Product Landscape
3.6. New Product Launches
3.7. Impact of COVID 19 on Market
4.Global RNA Synthesis Market Analysis, 2019 - 2023 and Forecast 2024 - 2030
4.1.  Market Analysis, 2019 - 2023 and Forecast, 2024 - 2030, (Sales Value USD Million)
4.2.  Year-Over-Year (Y-o-Y) Growth Analysis (%) 
4.3.  Market Opportunity Analysis 
5.Global RNA Synthesis Market  By  Technology, 2019 - 2023 and Forecast 2024 - 2030 (Sales Value USD Million)
5.1. In-Vitro Transcription
5.1.1. Market Analysis, 2019 - 2023 and Forecast, 2024 - 2030, (Sales Value USD Million)
5.1.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) 
5.1.3. Market Opportunity Analysis 
5.2. In-Vivo Transcription
5.2.1. Market Analysis, 2019 - 2023 and Forecast, 2024 - 2030, (Sales Value USD Million)
5.2.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) 
5.2.3. Market Opportunity Analysis 
5.3. Chemical Synthesis
5.3.1. Market Analysis, 2019 - 2023 and Forecast, 2024 - 2030, (Sales Value USD Million)
5.3.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) 
5.3.3. Market Opportunity Analysis 
6.Global RNA Synthesis Market  By End User, 2019 - 2023 and Forecast 2024 - 2030 (Sales Value USD Million)
6.1. Academic Research Institutes
6.1.1. Market Analysis, 2019 - 2023 and Forecast, 2024 - 2030, (Sales Value USD Million)
6.1.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) 
6.1.3. Market Opportunity Analysis 
6.2. Biopharmaceutical Companies
6.2.1. Market Analysis, 2019 - 2023 and Forecast, 2024 - 2030, (Sales Value USD Million)
6.2.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) 
6.2.3. Market Opportunity Analysis 
6.3. Contract Research Organization
6.3.1. Market Analysis, 2019 - 2023 and Forecast, 2024 - 2030, (Sales Value USD Million)
6.3.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) 
6.3.3. Market Opportunity Analysis 
7.Global RNA Synthesis Market  By Geography, 2019 - 2023 and Forecast 2024 - 2030 (Sales Value USD Million)
7.1. North America
7.1.1. Market Analysis, 2019 - 2023 and Forecast, 2024 - 2030, (Sales Value USD Million)
7.1.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) 
7.1.3. Market Opportunity Analysis 
7.2. Europe
7.2.1. Market Analysis, 2019 - 2023 and Forecast, 2024 - 2030, (Sales Value USD Million)
7.2.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) 
7.2.3. Market Opportunity Analysis 
7.3. The Asia Pacific
7.3.1. Market Analysis, 2019 - 2023 and Forecast, 2024 - 2030, (Sales Value USD Million)
7.3.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) 
7.3.3. Market Opportunity Analysis 
7.4. Latin America
7.4.1. Market Analysis, 2019 - 2023 and Forecast, 2024 - 2030, (Sales Value USD Million)
7.4.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) 
7.4.3. Market Opportunity Analysis 
7.5. Latin America
7.5.1. Market Analysis, 2019 - 2023 and Forecast, 2024 - 2030, (Sales Value USD Million)
7.5.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) 
7.5.3. Market Opportunity Analysis 
7.6. MEA
7.6.1. Market Analysis, 2019 - 2023 and Forecast, 2024 - 2030, (Sales Value USD Million)
7.6.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) 
7.6.3. Market Opportunity Analysis 
8.Global RNA Synthesis Market  By Region, 2019 - 2023 and Forecast 2024 - 2030 (Sales Value USD Million)
8.1. North America
8.1.1. Market Analysis, 2019 - 2023 and Forecast, 2024 - 2030, (Sales Value USD Million)
8.1.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) 
8.1.3. Market Opportunity Analysis 
8.2. Europe
8.2.1. Market Analysis, 2019 - 2023 and Forecast, 2024 - 2030, (Sales Value USD Million)
8.2.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) 
8.2.3. Market Opportunity Analysis 
8.3. Asia Pacific (APAC)
8.3.1. Market Analysis, 2019 - 2023 and Forecast, 2024 - 2030, (Sales Value USD Million)
8.3.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) 
8.3.3. Market Opportunity Analysis 
8.4. Middle East and Africa (MEA)
8.4.1. Market Analysis, 2019 - 2023 and Forecast, 2024 - 2030, (Sales Value USD Million)
8.4.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) 
8.4.3. Market Opportunity Analysis 
8.5. Latin America
8.5.1. Market Analysis, 2019 - 2023 and Forecast, 2024 - 2030, (Sales Value USD Million)
8.5.2. Year-Over-Year (Y-o-Y) Growth Analysis (%) and Market Share Analysis (%) 
8.5.3. Market Opportunity Analysis 
9.North America RNA Synthesis Market ,2019 - 2023 and Forecast 2024 - 2030 (Sales Value USD Million)
9.1.  Technology Analysis 2019 - 2023 and Forecast 2024 - 2030 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) 
9.1.1.In-Vitro Transcription
9.1.2.In-Vivo Transcription
9.1.3.Chemical Synthesis
9.2.  End User Analysis 2019 - 2023 and Forecast 2024 - 2030 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) 
9.2.1.Academic Research Institutes
9.2.2.Biopharmaceutical Companies
9.2.3.Contract Research Organization
9.3.  Geography Analysis 2019 - 2023 and Forecast 2024 - 2030 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) 
9.3.1.North America
9.3.2.Europe
9.3.3.The Asia Pacific
9.3.4.Latin America
9.3.5.Latin America
9.3.6.MEA
9.4.  Country Analysis 2019 - 2023 and Forecast 2024 - 2030 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) 
9.4.1.United States of America (USA)
9.4.2.Canada
10.Europe RNA Synthesis Market ,2019 - 2023 and Forecast 2024 - 2030 (Sales Value USD Million)
10.1.  Technology Analysis  and Forecast  by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) 
10.1.1.In-Vitro Transcription
10.1.2.In-Vivo Transcription
10.1.3.Chemical Synthesis
10.2.  End User Analysis 2019 - 2023 and Forecast 2024 - 2030 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) 
10.2.1.Academic Research Institutes
10.2.2.Biopharmaceutical Companies
10.2.3.Contract Research Organization
10.3.  Geography Analysis 2019 - 2023 and Forecast 2024 - 2030 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) 
10.3.1.North America
10.3.2.Europe
10.3.3.The Asia Pacific
10.3.4.Latin America
10.3.5.Latin America
10.3.6.MEA
10.4.  Country Analysis 2019 - 2023 and Forecast 2024 - 2030 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) 
10.4.1.Germany
10.4.2.France
10.4.3.Italy
10.4.4.United Kingdom (UK)
10.4.5.Spain
11.Asia Pacific (APAC) RNA Synthesis Market ,2019 - 2023 and Forecast 2024 - 2030 (Sales Value USD Million)
11.1.  Technology Analysis  and Forecast  by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) 
11.1.1.In-Vitro Transcription
11.1.2.In-Vivo Transcription
11.1.3.Chemical Synthesis
11.2.  End User Analysis 2019 - 2023 and Forecast 2024 - 2030 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) 
11.2.1.Academic Research Institutes
11.2.2.Biopharmaceutical Companies
11.2.3.Contract Research Organization
11.3.  Geography Analysis 2019 - 2023 and Forecast 2024 - 2030 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) 
11.3.1.North America
11.3.2.Europe
11.3.3.The Asia Pacific
11.3.4.Latin America
11.3.5.Latin America
11.3.6.MEA
11.4.  Country Analysis 2019 - 2023 and Forecast 2024 - 2030 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) 
11.4.1.China
11.4.2.India
11.4.3.Australia and New Zealand (ANZ)
11.4.4.Japan
11.4.5.Rest of APAC
12.Middle East and Africa (MEA) RNA Synthesis Market ,2019 - 2023 and Forecast 2024 - 2030 (Sales Value USD Million)
12.1.  Technology Analysis  and Forecast  by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) 
12.1.1.In-Vitro Transcription
12.1.2.In-Vivo Transcription
12.1.3.Chemical Synthesis
12.2.  End User Analysis 2019 - 2023 and Forecast 2024 - 2030 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) 
12.2.1.Academic Research Institutes
12.2.2.Biopharmaceutical Companies
12.2.3.Contract Research Organization
12.3.  Geography Analysis 2019 - 2023 and Forecast 2024 - 2030 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) 
12.3.1.North America
12.3.2.Europe
12.3.3.The Asia Pacific
12.3.4.Latin America
12.3.5.Latin America
12.3.6.MEA
12.4.  Country Analysis 2019 - 2023 and Forecast 2024 - 2030 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) 
12.4.1.GCC Countries
12.4.2.South Africa
12.4.3.Rest of MEA
13.Latin America RNA Synthesis Market ,2019 - 2023 and Forecast 2024 - 2030 (Sales Value USD Million)
13.1.  Technology Analysis  and Forecast  by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) 
13.1.1.In-Vitro Transcription
13.1.2.In-Vivo Transcription
13.1.3.Chemical Synthesis
13.2.  End User Analysis 2019 - 2023 and Forecast 2024 - 2030 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) 
13.2.1.Academic Research Institutes
13.2.2.Biopharmaceutical Companies
13.2.3.Contract Research Organization
13.3.  Geography Analysis 2019 - 2023 and Forecast 2024 - 2030 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) 
13.3.1.North America
13.3.2.Europe
13.3.3.The Asia Pacific
13.3.4.Latin America
13.3.5.Latin America
13.3.6.MEA
13.4.  Country Analysis 2019 - 2023 and Forecast 2024 - 2030 by Sales Value USD Million, Y-o-Y Growth (%), and Market Share (%) 
13.4.1.Brazil
13.4.2.Mexico
13.4.3.Rest of LA
14. Competition Landscape
14.1.  Market Player Profiles (Introduction, Brand/Product Sales, Financial Analysis, Product Offerings, Key Developments, Collaborations, M & A, Strategies, and SWOT Analysis) 
14.2.1.Aldevron
14.2.2.Aurigene Pharmaceutical Services
14.2.3.Biomay
14.2.4.Curia
14.2.5.eTheRNA
14.2.6.Eurogentec
14.2.7.Genscript
14.2.8.Merck KGaA
14.2.9.TriLink BioTechnologies
14.2.10.Vernal Biosciences
14.2.11.WuXi Biologics
14.2.12.Maravai LifeSciences
14.2.13.Yeasen Biotechnology (Shanghai) Co., Ltd.
14.2.14.Thermo Fisher Scientific, Inc.
14.2.15.New England Biolabs
15. Research Methodology 
16. Appendix and Abbreviations 

Key Market Players

  • Aldevron
  • Aurigene Pharmaceutical Services
  • Biomay
  • Curia
  • eTheRNA
  • Eurogentec
  • Genscript
  • Merck KGaA
  • TriLink BioTechnologies
  • Vernal Biosciences
  • WuXi Biologics
  • Maravai LifeSciences
  • Yeasen Biotechnology (Shanghai) Co., Ltd.
  • Thermo Fisher Scientific, Inc.
  • New England Biolabs

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