Hyaluronic Acid Market Size, Share, Growth, Trends, and Global Industry Analysis: By Form (Solid, Liquid), By Application (Dermal Fillers, Osteoarthritis, Ophthalmic, Vesicoureteral Reflux), By End User (Pharmaceutical Industry, Cosmetic Surgery Centers, Dermatology Clinics, Others) and Region 2020-2031

Hyaluronic Acid Market size was valued at US$ 10,562.8 million in 2024 and is expected to reach US$ 15,987.7 million by 2031, growing at a significant CAGR of 5.8% from 2025-2031. Moreover, the U.S. market is projected to grow at 6.2% over the forecast period. The hyaluronic acid market refers to the global industry involved in the production, distribution, and application of hyaluronic acid (HA), a naturally occurring glycosaminoglycan found in the human body that plays a vital role in maintaining moisture, elasticity, and tissue repair. It is widely used across various industries, including pharmaceuticals, cosmetics, nutraceuticals, and ophthalmology, due to its hydrating and viscoelastic properties. The market encompasses a range of HA-based products such as dermal fillers, eye drops, dietary supplements, and intra-articular injections used for treating osteoarthritis and skin aging.

The hyaluronic acid market is experiencing strong growth driven by rising demand for minimally invasive aesthetic procedures, an aging population, and increasing awareness of skin health. Expanding applications in orthopedics, wound healing, and drug delivery further contribute to market expansion. Technological advancements in biofermentation and cross-linking techniques have enhanced product quality and shelf life, boosting adoption. The Asia-Pacific region is emerging as a key growth hub due to a surge in cosmetic procedures, while North America and Europe continue to dominate due to high healthcare spending and established cosmetic industries. Overall, the market is poised for continued growth, supported by innovation and expanding therapeutic applications.

Facts & Figures 

• According to the U.S. FDA’s Voluntary Cosmetic Registration Program (VCRP) data (2023), sodium hyaluronate is used in 4,713 total formulations (4,317 leave-on, 394 rinse-off, 2 diluted for bath use), making it the hyaluronate ingredient with the highest frequency of use.
• Hyaluronic acid used as a dermal filler is absorbable/temporary. It is often chemically modified (cross-linked) to last longer typical duration of effects is about 6–12 months for HA fillers.
• In 2019, it was estimated that nearly 2.2 million injection procedures in the United States used hyaluronic acid as the dermal filler material.

Key Developments 

• In February 2025, Evolus, Inc., announced that the Evolysse Form and Evolysse Smooth injectable hyaluronic-acid gels received regulatory approval from the U.S. Food & Drug Administration (FDA). The company stated these products represent the first major technological advancement in HA dermal fillers in a decade and will mark its entry into the U.S. HA filler market. This move expands Evolus’s total addressable market by approximately 78 % and is planned for a U.S. commercial launch in Q2 2025.
• In March 2025, Juvéderm®?Voluma®?XC (by Allergan Aesthetics/AbbVie) was approved by the FDA for the treatment of moderate to severe temple hollowing in adults 21 years and older. This marked the first HA dermal filler specifically approved for the upper-face temple region, with reported effects lasting up to 13 months.
• In September 2025, Obagi®?saypha®?MagIQ™, a hyaluronic-acid injectable gel built on proprietary MacroCore technology, received FDA approval. This approval positions Obagi Medical’s entry into the U.S. dermal-filler market and is expected to significantly broaden its addressable market by 2029. A U.S. launch is slated for 2026.

Hyaluronic Acid Market Segmentation

Based on the form

• Solid
• Liquid

The liquid form of hyaluronic acid is anticipated to lead the market, primarily driven by its extensive applications in cosmetics, pharmaceuticals, and medical aesthetics. In liquid form, HA offers superior versatility, it can be easily incorporated into injectable fillers, serums, eye drops, and topical formulations. Its high solubility and compatibility with biological tissues make it ideal for dermal filler injections, viscosupplementation treatments, and ophthalmic solutions. The growing global demand for non-surgical cosmetic procedures, including facial contouring and anti-aging treatments, further accelerates the adoption of liquid HA. Additionally, in skincare, hyaluronic acid serums and ampoules are widely favored due to their rapid absorption and deep hydration benefits. The liquid form also allows for precise dosing and customization across pharmaceutical formulations. With ongoing innovation in cross-linked HA gels and advanced delivery systems, the liquid segment is expected to maintain its leadership position in both therapeutic and aesthetic applications.

Based on the application

• Dermal Fillers
• Osteoarthritis
• Ophthalmic
• Vesicoureteral Reflux

Dermal fillers represent the leading application segment in the hyaluronic acid market, primarily driven by the surging demand for non-invasive aesthetic procedures worldwide. Hyaluronic acid-based fillers are highly favored due to their natural compatibility with human tissue, excellent hydration properties, and reversible nature, which enhance both safety and patient satisfaction. The growing societal emphasis on youthful appearance, coupled with the rise of social media influence and self-care trends, has significantly increased the number of cosmetic procedures, particularly among younger demographics. Furthermore, technological advancements in cross-linking methods have improved the longevity and stability of HA fillers, offering longer lasting and more natural results. Dermatologists and aesthetic clinics increasingly prefer HA fillers for facial contouring, wrinkle reduction, and lip enhancement because of their precision and minimal recovery time. With continuous FDA approvals and expanding clinical indications, the dermal filler segment is anticipated to remain the dominant driver of the hyaluronic acid market’s growth.

Based on the end user

• Pharmaceutical Industry
• Cosmetic Surgery Centers
• Dermatology Clinics
• Others

Dermatology clinics are anticipated to lead the hyaluronic acid market due to the increasing global preference for professional, clinic-based aesthetic treatments and skin rejuvenation procedures. These clinics serve as the primary hubs for administering HA-based dermal fillers, mesotherapy, and anti-aging therapies, ensuring safe and effective outcomes under expert supervision. The rising consumer inclination toward personalized skincare solutions and minimally invasive cosmetic enhancements has significantly boosted patient footfall in dermatology centers. Moreover, dermatologists are adopting advanced HA formulations with improved viscoelasticity and longer duration of effect, enhancing patient satisfaction and repeat treatment rates. The expansion of dermatology chains in both developed and emerging economies, supported by medical tourism and greater awareness of aesthetic science, further strengthens this dominance. As dermatology clinics increasingly integrate digital consultation platforms and AI-based skin assessment tools, they are expected to remain the key end users driving innovation and revenue in the hyaluronic acid market.