Ligase Market Size, Share, Growth, Trends, and Global Industry Analysis: Size, Share, Growth, Trends, and Industry Analysis By Product (Quick Ligase, T4 DNA Ligase, E. coli DNA Ligase, Tth DNA Ligase, T4 RNA Ligase, Pfu DNA Ligase & Others), By Source (Microorganisms, Animal, Plant), By Applications (Ligase Chain Reaction, Ligase Detection Reaction, Next-Generation Sequencing, Repeat Expansion Detection, Rolling Circle Amplification, Proximity Ligation Assay, Molecular Cloning, Ligation Mediated PCR, Mutation Detection & Others), By End User (Research Laboratories and Institutions, Pharmaceutical and Biopharmaceutical Companies, Diagnostic Laboratories & Others), and Region Forecast 2019-2030

Ligase market size was valued at US$ 401.6 million in 2023 and is projected to reach a value of US$ 615.9 million by 2030, at a CAGR of 6.3% from 2024-2030. Ligases are enzymes that catalyse the joining (ligation) of two large molecules by forming a new chemical bond, typically associated with the conservation of chemical energy, they play a crucial role in various biological processes, including DNA replication and repair. They typically form new bonds by hydrolyzing a small chemical group on one of the molecules. The growth factors of the market are growing need for ligases in disease treatment, rising incidence of diseases such as cancer and genetic disorders, rising focus of researchers on non-toxic biocatalyst.

However, the constraints of the market are high cost of production, dependency on research funding. The emerging opportunities of the market are expansion in gene editing and therapy, innovations in CRISPR technology and gene-editing tools, development of novel ligase variants. The key trends of the market are development of thermostable ligases, innovations in enzyme engineering.

Key Players

The leading companies highlighted in the ligase market report include such as Agilent Technologies Inc offers products like DNA Ligation Kit, Pfu DNA Ligase ; ArcticZymes Technologies ASA offers a unique product in the market called ArcticZymes R2D Ligase ; Bio-Rad Laboratories Inc offers products like Ligation and Transformation Module, Proofreading DNA Polymerase ; Codexis Inc offers products and services primarily focused on RNA synthesis and pharmaceutical manufacturing ; Hoffmann-La Roche Ltd offers products related primarily for use in DNA library preparation and next-generation sequencing (NGS) ; Inspiralis Limited Inc has products like T4 DNA Ligase, Assay Kits ; Merck KGaA offers several ligase-related products, primarily under their Sigma-Aldrich brand such as T4 DNA Ligase – Novagen and others.

Also, a comprehensive analysis of industry verticals and market participants that provides a clear overview of the competitive landscape in relation to the sectors served by the company’s products and services, market share, service offerings, financial reports, significant developments, market strategy, competitive position, and geographic reach.

Key Takeaways

• North America market is the dominant market in 2023.
• Asia Pacific ligase market is expected to expand at highest CAGR from 2024 to 2030.
• Based on product, the T4 DNA ligase segment dominated the market in 2023.
• Based on source, the microorganisms has captured the highest share in the market.
• Based on application, the molecular cloning segment has expected to dominate the the market in coming forecast years.
• Based on end user, the research laboratories and institutions account the largest share in themarket.

Facts & Figures

• In January 2022, ArcticZymes Technologies launched new products such as ArcticZymes R2DTM Ligase, IsoPol BST+ High Concentration Glycerol FREE and M-SAN HQ ELISA Kit and M-SAN HQ.
• In May 2022, QIAGEN acquired majority stake of 96% in BLIRT e.u.., a manufacturer of recombinant enzymes for the life science industry based in Gdansk, Poland. The acquisition was carried out to bring companies capabilities to create additional growth prospects to their enzymes and reagents business

Key Developments

In April 2022, Codexis, Inc. and Molecular Assemblies, Inc., partnered to engineer enzymes and deliver differentiated and cost-effective solutions for the enzymatic synthesis of DNA.

Ligase Market Segmentation

By Product: Among the all products, the T4 DNA ligase segment dominated the market. This enzyme, originally derived from the T4 bacteriophage, is widely used for its high efficiency in joining DNA fragments with sticky or blunt ends, making it essential for various molecular biology applications. Its extensive use in cloning, next-generation sequencing, and genetic engineering drove significant demand. The enzyme’s ability to facilitate accurate and efficient DNA ligation in both research and clinical settings contributed to its dominance.

By Source: Among the all sources, microorganisms category has captured the highest share in the market. This is primarily due to the widespread use of enzymes derived from microorganisms like Escherichia coli (E. coli) and Thermus thermophilus, these microorganisms are preferred sources for ligase production because they can be easily cultured and genetically manipulated to produce high yields of the desired enzymes. The high efficiency, stability, and cost-effectiveness of microbial ligases make them the dominant choice for various applications in molecular biology, diagnostics, and therapeutics. As a result, the microorganism-based ligase segment continues to lead the market.

By Application: Among the applications, molecular cloning segment is expected to dominate the market in the coming forecast years due to its fundamental role in genetic engineering and biotechnology research. Molecular cloning involves the creation of recombinant DNA molecules, and ligases. As the demand for genetic research, gene therapy, and synthetic biology continues to grow, the need for efficient and reliable molecular cloning techniques increases. This drives the demand for high-quality ligases. Additionally, advancements in cloning technologies and the development of new ligase variants with enhanced properties are further boosting the adoption of ligases in molecular cloning applications, solidifying its leading position in the market.

By End User: Among all the end users, research laboratories and institutions account for the largest share in the market. This dominance is driven by the extensive use of ligases in molecular biology research, including DNA cloning, sequencing, and gene editing. Academic and governmental research institutions continually conduct experiments that require reliable and high-quality ligases, contributing to their significant market share. Additionally, ongoing advancements in genetic research and biotechnology, coupled with substantial funding for life sciences research, further fuel the demand for ligases in these settings.